Author Archives

Klaus D Linse , Ph.D
Director of Scientific Operations
klaus_linse@biosyn.com
www.biosyn.com
612 East Main Street, Lewisville, Texas 75057-4052
1-972-420-8505

• Antimicrobial Resistance Mechanisms

  By Klaus D. Linse on June 6, 2017 • ( 0 )

  

  
  

  Gram-negative pathogens, such as Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii are now responsible for many infections, including infections occurring in hospitals. Because of their broad spectrum of antibiotic resistance many antibiotics may now longer work well. A few years after… Read More ›

• Teixobactin, a new antibiotic peptide that has the potential to avoid the development of resistance

  By Klaus D. Linse on February 1, 2016 • ( 0 )

  

  
  

  Teixobactin is a newly discovered natural occurring antibiotic peptide. Teixobactin is a newly discovered antibiotic peptide identified from soil samples using isolation chip (iChip, Ichip, or ichip) technology. In recent years, researchers developed the iChip technology to allow for the… Read More ›

• Streptide, a newly discovered naturally occuring cyclic peptide

  By Klaus D. Linse on April 30, 2015 • ( 0 )

  

  
  

  —  …  — Streptide is a newly discovered macrocyclic naturally occurring streptococcal peptide. Streptococcal bacteria are thought to use peptides as communication signals. Often these types of peptides contain unusual post-translational modifications. Many different biosynthetic strategies for the formation of… Read More ›

• Cancer genes and food that fight cancer

  By Klaus D. Linse on April 27, 2015 • ( 1 )

  

  
  

  News from the Annual Meeting of the American Association for Cancer Research (AACR) 2015 held in Philadelphia April 18 – 22, 2015 at the Pennsylvania Convention Center, Philadelphia, Pennsylvania http://www.aacr.org/Meetings/Page/MeetingDetail.aspx?EventItemID=25 Disclaimer: Due to the many posters and program items covered… Read More ›

• How does the BNA[NC] bead-based assay for somatic mutations work?

  By Klaus D. Linse on June 16, 2014 • ( 1 )

  

  
  

  Shivarov et al. designed and validated this BNA[NC] probe bead-based assay for the Luminex Lab Scan 200 flow platform to allow for the detection and quantification of somatic mutations in Leukemia! -.- How does the assay work? Primers are designed… Read More ›

• A novel BNA[NC] bead-based assay for somatic mutations in Leukemia

  By Klaus D. Linse on June 13, 2014 • ( 5 )

  

  
  

  Shivarov et al. designed and validated a novel bead-based suspension assay using BNA[NC] probes for the Luminex Lab Scan 200 flow platform to detect and quantify somatic mutations in Leukemia! -.- Shivarov et al. recently develop and validated a novel bead-based… Read More ›

• Web resources for the CRISPR Cas System!

  By Klaus D. Linse on January 15, 2014 • ( 1 )

  
  

  Drosophila CRISPR Web Resources Name Link Description OxfCRISPR (Liu Lab) http://www.oxfcrispr.org Oxford Fly CRISPR Resources CRISPRflydesign (Bullock Lab) http://www.crisprflydesign.org/ Offers Cas9 transgenic stocks DRSC CRISPR finder (Perrimon Lab) http://www.flyrnai.org/crispr/ A web tool to identify CRISPRs for fly study FlyCas9 (Ueda… Read More ›

• How can the CRISPR Cas System be used?

  By Klaus D. Linse on January 15, 2014 • ( 0 )

  
  

  Potential Uses or Applications of the CRISPR Cas System ! -.- Several Uses of Cas9 Induced Double Strand Breaks for Genomic Engineering as Suggested by Basset and Li in 2014 are listed below. -.- Most applications of CRISPR Cas9 use… Read More ›

• Structural Models of the CRISPR Cas System!

  By Klaus D. Linse on January 15, 2014 • ( 0 )

  

  
  

  As of December 2013 90 solved structures were available in the PubMed structural database related to the CRISPR Cas System! -.- A few these models are shown below! A PubMed search for “CRISPR Cas” showed that close to 90 solved… Read More ›

• Highlighted Reports on the CRISPR Cas System!

  By Klaus D. Linse on January 15, 2014 • ( 1 )

  
  

  Selected papers for CRISPR Cas! Segal and Meckler in 2013 state in ‘Genome Engineering at the Dawn of the Golden Age,’ that, “In summary, compared with ZFNs, TALENs can be designed for more targets, are more likely to be active… Read More ›