Author Archives

Klaus D Linse , Ph.D
Director of Scientific Operations
klaus_linse@biosyn.com
www.biosyn.com
612 East Main Street, Lewisville, Texas 75057-4052
1-972-420-8505

• Is Targeted Insertion of Short DNA Fragments into Mammalian Cells Possible?

  By Klaus D. Linse on January 15, 2014 • ( 1 )

  

  
  

  Recently the Targeted Insertion of Short DNA Fragments into Mammalian Cells was Shown to be Possible with the help of CRISPR Cas! The direct injection of Cas9 mRNA, sgRNAs, and DNA oligos or vectors into mammalian cells was reported as… Read More ›

• What is a CRISPR Cas system?

  By Klaus D. Linse on January 15, 2014 • ( 1 )

  

  
  

  The CRISPR-Cas systems found in bacteria and archaea are versatile small RNAs for adaptive defense and regulation Bacteria and archaea have evolved various defense and regulatory mechanisms allowing them to react to various stressful situations caused by the environment, such… Read More ›

• How do we taste or smell odors?

  By Klaus D. Linse on December 24, 2013 • ( 1 )

  

  
  

  The taste of sugars amino acids, peptides, nucleotides, and proteins “Analytical Services” Taste and smell are chemical senses that give us humans and many animals information about the chemical composition that surround us and are part of our nearest environment. … Read More ›

• What are Circular Oligonucleotides?

  By Klaus D. Linse on September 11, 2013 • ( 0 )

  

  
  

  Circular oligonucleotides are covalently closed singular DNA or RNA strands that are resistant to degradation by many cellular DNA and RNA decay machineries. [Source: (left) Modelling DNA; Phil. Trans. R. Soc. A-2006-Harris-3319-34; (right) David Goodsell: The self-splicing RNA in PDB… Read More ›

• Peptides – a collection of words, nouns and terms to review – natural peptides, synthetic peptides, peptide mimics, artificial peptides, modified peptides and more.

  By Klaus D. Linse on September 4, 2013 • ( 2 )

  

  
  

  WHAT ARE PEPTIDES? Peptides are macro molecules that contain amino acid monomers linked together by peptide (amide) bonds. The covalent bonds are formed when the carboxyl group of one amino acid reacts with the amino group of another. Peptides are… Read More ›

• Are MicroRNAs the new players in metabolism and metabolic disorders?

  By Klaus D. Linse on August 30, 2013 • ( 1 )

  

  
  

  Micro RNAs (miRNAs) have recently emerged as key regulators of metabolic processes! . More and more evidence is accumulating that suggest that the dysregulation of miRNAs may contribute to metabolic abnormalities such as the misregulation of cholesterol and lipid metabolism, insulin… Read More ›

• What are Nano-flares? What are the features of nano-flares?

  By Klaus D. Linse on August 29, 2013 • ( 0 )

  

  
  

  Answer 1 . A “nano-flare” refers to a very small solar flare that happens in the corona, the external atmosphere of the Sun. . Answer 2 . Nano-flares are a new class of intracellular molecular probes. . This blog is… Read More ›

• What is “3-phosphoglyceryl-lysine or pgK”?

  By Klaus D. Linse on August 8, 2013 • ( 3 )

  

  
  

  “3-phosphoglyceryl-lysine or pgK” is a newly discovered functional protein modification! The more scientists look the more they find ! . Can this new functional amino acid modification provide insights in the causes of diabetes, cancer, and other metabolic disorders in… Read More ›

• What is the “intelligent knife” also called “iKnife” or REIMS?

  By Klaus D. Linse on July 25, 2013 • ( 5 )

  

  
  

  It is a new mass spectrometry based technique that could be used routinely for cancer diagnostics and surgery in the future! . It is a cancer knife that identifies tumor cells!  . The news section of the Journal of Science… Read More ›

• Are viruses hiding within us?

  By Klaus D. Linse on July 24, 2013 • ( 2 )

  

  
  

  Recent research results indicate that viral sequences are part of us. Endogenous viral elements (EVEs) or endogenous retroviral elements (ERVs) have been identified in eukaryotic genomes including the human genome. The findings revealed the enormous scale of the invasion of… Read More ›