Author Archives

Klaus D Linse , Ph.D
Director of Scientific Operations
klaus_linse@biosyn.com
www.biosyn.com
612 East Main Street, Lewisville, Texas 75057-4052
1-972-420-8505

• How can the CRISPR Cas System be used?

  By Klaus D. Linse on January 15, 2014 • ( 0 )

  
  

  Potential Uses or Applications of the CRISPR Cas System ! -.- Several Uses of Cas9 Induced Double Strand Breaks for Genomic Engineering as Suggested by Basset and Li in 2014 are listed below. -.- Most applications of CRISPR Cas9 use… Read More ›

• Structural Models of the CRISPR Cas System!

  By Klaus D. Linse on January 15, 2014 • ( 0 )

  

  
  

  As of December 2013 90 solved structures were available in the PubMed structural database related to the CRISPR Cas System! -.- A few these models are shown below! A PubMed search for “CRISPR Cas” showed that close to 90 solved… Read More ›

• Highlighted Reports on the CRISPR Cas System!

  By Klaus D. Linse on January 15, 2014 • ( 1 )

  
  

  Selected papers for CRISPR Cas! Segal and Meckler in 2013 state in ‘Genome Engineering at the Dawn of the Golden Age,’ that, “In summary, compared with ZFNs, TALENs can be designed for more targets, are more likely to be active… Read More ›

• Is Targeted Insertion of Short DNA Fragments into Mammalian Cells Possible?

  By Klaus D. Linse on January 15, 2014 • ( 1 )

  

  
  

  Recently the Targeted Insertion of Short DNA Fragments into Mammalian Cells was Shown to be Possible with the help of CRISPR Cas! The direct injection of Cas9 mRNA, sgRNAs, and DNA oligos or vectors into mammalian cells was reported as… Read More ›

• What is a CRISPR Cas system?

  By Klaus D. Linse on January 15, 2014 • ( 1 )

  

  
  

  The CRISPR-Cas systems found in bacteria and archaea are versatile small RNAs for adaptive defense and regulation Bacteria and archaea have evolved various defense and regulatory mechanisms allowing them to react to various stressful situations caused by the environment, such… Read More ›

• How do we taste or smell odors?

  By Klaus D. Linse on December 24, 2013 • ( 1 )

  

  
  

  The taste of sugars amino acids, peptides, nucleotides, and proteins “Analytical Services” Taste and smell are chemical senses that give us humans and many animals information about the chemical composition that surround us and are part of our nearest environment. … Read More ›

• What are Circular Oligonucleotides?

  By Klaus D. Linse on September 11, 2013 • ( 0 )

  

  
  

  Circular oligonucleotides are covalently closed singular DNA or RNA strands that are resistant to degradation by many cellular DNA and RNA decay machineries. [Source: (left) Modelling DNA; Phil. Trans. R. Soc. A-2006-Harris-3319-34; (right) David Goodsell: The self-splicing RNA in PDB… Read More ›