Author Archives

Klaus D Linse , Ph.D
Director of Scientific Operations
klaus_linse@biosyn.com
www.biosyn.com
612 East Main Street, Lewisville, Texas 75057-4052
1-972-420-8505

• Thermodynamics of DNA Hybridization

  By Klaus D. Linse on May 10, 2013 • ( 1 )

  

  
  

  Knowledge of DNA thermodynamics is crucial for the design of PCR probes or any other oligonucleotide based hybridization probe! . Since DNA hybridization does not strictly follow the Watson-Crick pairing rules DNA hybridization experiments often require optimization. A DNA oligonucleotide… Read More ›

• What are Micro peptides?

  By Klaus D. Linse on May 7, 2013 • ( 3 )

  

  
  

  Micro peptides are short, unprocessed peptides with biological functions! . Do noncoding RNAs (ncRNAs) code for micro peptides? . Yes, apparently this appears to be the case! . In protein synthesis RNA acts as a template for cellular proteins and… Read More ›

• What are MicroRNAs and what do they do?

  By Klaus D. Linse on May 3, 2013 • ( 11 )

  
  

  MicroRNAs are small non-coding single-stranded RNA molecules MicroRNAs (miRNAs) are small non-coding single-stranded RNA molecules consisting of approximately 21 to 22 nucleotides that regulate posttranscriptional gene expression in metazoans and plants. miRNAs are usually generated from noncoding regions of gene… Read More ›

• What are MicroRNA sponges?

  By Klaus D. Linse on May 3, 2013 • ( 1 )

  
  

  MicroRNA sponges are decoy targets for miRNA seed families ! Ebert, Neilson & Sharp in 2007 report how to make decoy targets for several microRNA seed families, and named them ‘microRNA sponges’. Furthermore the researchers tested their ability to derepress… Read More ›

• A New Approach to Cancer Therapy

  By Klaus D. Linse on May 1, 2013 • ( 0 )

  

  
  

  Poster 5319 presented by Dr. Masamitsu Konno reports a new way for a cancer therapy to treat Gastrointestinal Cancer . The title of the poster presented in the AACR 2013 Meeting poster session on Wednesday morning in the section “Non-Coding… Read More ›

• Why are some infections with certain flu virus strains fatal and others are not?

  By Klaus D. Linse on April 30, 2013 • ( 1 )

  

  
  

  The answer may be found in human CD4+ T cells Virus specific memory CD4+ T cells numbers predict the outcome of human influenza infections Wilkinson et al. in 2012 showed that  CD4+ T cells that are activated by earlier influenza virus… Read More ›

• Peptides for Influenza Research

  By Klaus D. Linse on April 30, 2013 • ( 0 )

  

  
  

  Synthetic peptides are versatile tools to help develop vaccines against new Influenza A viral strains Pools or libraries of synthetic peptides derived from Influenza A viral proteins can be used to screen for and identify human leukocyte class I (HLA-I)… Read More ›

• Tales of Genes and Proteins

  By Klaus D. Linse on April 26, 2013 • ( 1 )

  

  
  

  Implications of the Human Genome Project The human genome project revealed that the human genome contains approximately 26,000 to 38,000 genes that code for proteins. This is significantly fewer than had been previously anticipated. It was found that protein-coding sequences… Read More ›

• The RNA world is still expanding !

  By Klaus D. Linse on April 25, 2013 • ( 0 )

  

  
  

  The ever expanding world of RNA RNA or ribonucleic acids differ from DNA or deoxyribonucleic acids in having the sugar ribose in place of deoxyribose as well as having one less oxygen atom at the ribose. Secondly, in RNA the… Read More ›

• Happy DNA Week!

  By Klaus D. Linse on April 24, 2013 • ( 0 )

  

  
  

  This week is the international DNA week! . This year we celebrate the 60th anniversary of the discovery of the DNA double helix by Watson and Crick which was achieved with the help of X-ray diffraction data produced by Rosalind… Read More ›