Shivarov et al. designed and validated this BNA[NC] probe bead-based assay for the Luminex Lab Scan 200 flow platform to allow for the detection and quantification of somatic mutations in Leukemia! -.- How does the assay work? Primers are designed… Read More ›
Bridged Nucleic Acid
A novel BNA[NC] bead-based assay for somatic mutations in Leukemia
Shivarov et al. designed and validated a novel bead-based suspension assay using BNA[NC] probes for the Luminex Lab Scan 200 flow platform to detect and quantify somatic mutations in Leukemia! -.- Shivarov et al. recently develop and validated a novel bead-based… Read More ›
What are Nano-flares? What are the features of nano-flares?
Answer 1 . A “nano-flare” refers to a very small solar flare that happens in the corona, the external atmosphere of the Sun. . Answer 2 . Nano-flares are a new class of intracellular molecular probes. . This blog is… Read More ›
RNA FISH can be used to visualize subcellular locations of RNA or RNA-RBP complexes including the location of noncoding RNAs !
RNA FISH allows the identification and localization of noncoding RNAs in cells ! Ribonucleic Acid Fluorescence In Situ Hybridization (RNA FISH) is a visualization technique that allows simultaneous detection, localization, and quantification of individual RNA molecules at the subcellular level…. Read More ›
Bridged Nucleic Acid based FISH
Bridged Nucleic Acid (BNA) based FISH probes are smart tools available from Biosynthesis Inc. Recent advancements in the design and development of molecular probes and image analysis has made fluorescence in situ hybridization (FISH) a powerful tool. Although being a… Read More ›
A New Approach to Cancer Therapy
Poster 5319 presented by Dr. Masamitsu Konno reports a new way for a cancer therapy to treat Gastrointestinal Cancer . The title of the poster presented in the AACR 2013 Meeting poster session on Wednesday morning in the section “Non-Coding… Read More ›
Q-FISHing to monitor molecular aging
By Klaus D. Linse Fluorescence In Situ Hybridization (FISH) for Telomere Length Quantification or Q-FISH evolves into High-Throughput Q-FISH Fluorescence in situ hybridization (FISH) is a powerful tool and probes that exhibit high DNA and RNA affinities promise to improve… Read More ›
A brief history of Bridged Nucleic Acids (BNAs)
By Klaus D. Linse 01/03/2013 A quest for better oligonucleotide mimics. The quest for oligonucleotide mimics with improved characteristics and stabilities useful for molecular diagnostics and therapeutics that also show minimal side effects has led to the design and synthesis… Read More ›