Drosophila CRISPR Web Resources Name Link Description OxfCRISPR (Liu Lab) http://www.oxfcrispr.org Oxford Fly CRISPR Resources CRISPRflydesign (Bullock Lab) http://www.crisprflydesign.org/ Offers Cas9 transgenic stocks DRSC CRISPR finder (Perrimon Lab) http://www.flyrnai.org/crispr/ A web tool to identify CRISPRs for fly study FlyCas9 (Ueda… Read More ›
miRNA
How can the CRISPR Cas System be used?
Potential Uses or Applications of the CRISPR Cas System ! -.- Several Uses of Cas9 Induced Double Strand Breaks for Genomic Engineering as Suggested by Basset and Li in 2014 are listed below. -.- Most applications of CRISPR Cas9 use… Read More ›
What are Circular Oligonucleotides?
Circular oligonucleotides are covalently closed singular DNA or RNA strands that are resistant to degradation by many cellular DNA and RNA decay machineries. [Source: (left) Modelling DNA; Phil. Trans. R. Soc. A-2006-Harris-3319-34; (right) David Goodsell: The self-splicing RNA in PDB… Read More ›
Are MicroRNAs the new players in metabolism and metabolic disorders?
Micro RNAs (miRNAs) have recently emerged as key regulators of metabolic processes! . More and more evidence is accumulating that suggest that the dysregulation of miRNAs may contribute to metabolic abnormalities such as the misregulation of cholesterol and lipid metabolism, insulin… Read More ›
What are Nano-flares? What are the features of nano-flares?
Answer 1 . A “nano-flare” refers to a very small solar flare that happens in the corona, the external atmosphere of the Sun. . Answer 2 . Nano-flares are a new class of intracellular molecular probes. . This blog is… Read More ›
RNA FISH can be used to visualize subcellular locations of RNA or RNA-RBP complexes including the location of noncoding RNAs !
RNA FISH allows the identification and localization of noncoding RNAs in cells ! Ribonucleic Acid Fluorescence In Situ Hybridization (RNA FISH) is a visualization technique that allows simultaneous detection, localization, and quantification of individual RNA molecules at the subcellular level…. Read More ›
Piwi-RNAs, the Defenders of the Genome
What are Piwi- or piRNAs ? Here is the answer: P-element induced wimpy testis (Piwi)-RNAs, or Piwi-interacting RNA, or piRNAs are small RNAs typically 23 to 35 nucleotides long . . During the recent 16 years a group of small… Read More ›
What are MicroRNAs and what do they do?
MicroRNAs are small non-coding single-stranded RNA molecules MicroRNAs (miRNAs) are small non-coding single-stranded RNA molecules consisting of approximately 21 to 22 nucleotides that regulate posttranscriptional gene expression in metazoans and plants. miRNAs are usually generated from noncoding regions of gene… Read More ›
What are MicroRNA sponges?
MicroRNA sponges are decoy targets for miRNA seed families ! Ebert, Neilson & Sharp in 2007 report how to make decoy targets for several microRNA seed families, and named them ‘microRNA sponges’. Furthermore the researchers tested their ability to derepress… Read More ›
A New Approach to Cancer Therapy
Poster 5319 presented by Dr. Masamitsu Konno reports a new way for a cancer therapy to treat Gastrointestinal Cancer . The title of the poster presented in the AACR 2013 Meeting poster session on Wednesday morning in the section “Non-Coding… Read More ›
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