Gram-negative pathogens, such as Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii are now responsible for many infections, including infections occurring in hospitals. Because of their broad spectrum of antibiotic resistance many antibiotics may now longer work well. A few years after… Read More ›
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RNA FISH can be used to visualize subcellular locations of RNA or RNA-RBP complexes including the location of noncoding RNAs !
RNA FISH allows the identification and localization of noncoding RNAs in cells ! Ribonucleic Acid Fluorescence In Situ Hybridization (RNA FISH) is a visualization technique that allows simultaneous detection, localization, and quantification of individual RNA molecules at the subcellular level…. Read More ›
A brief history of Bridged Nucleic Acids (BNAs)
By Klaus D. Linse 01/03/2013 A quest for better oligonucleotide mimics. The quest for oligonucleotide mimics with improved characteristics and stabilities useful for molecular diagnostics and therapeutics that also show minimal side effects has led to the design and synthesis… Read More ›
Peptide Based Vaccines For Immunotherapies
By Klaus D. Linse Can synthetic peptides be used for the development of vaccines against cancer cells? Many medical scientists think the answer is yes. In a study published by Schwartzentruber et al. in the “New England Journal of… Read More ›