Shivarov et al. designed and validated a novel bead-based suspension assay using BNA[NC] probes for the Luminex Lab Scan 200 flow platform to detect and quantify somatic mutations in Leukemia! -.- Shivarov et al. recently develop and validated a novel bead-based… Read More ›
probes
Are viruses hiding within us?
Recent research results indicate that viral sequences are part of us. Endogenous viral elements (EVEs) or endogenous retroviral elements (ERVs) have been identified in eukaryotic genomes including the human genome. The findings revealed the enormous scale of the invasion of… Read More ›
What do long noncoding RNAs and Pseudogenes do?
Pseudogene long noncoding RNA networks appear to regulate transcription and translation in human cells. What are pseudogenes? Pseudogenes are now thought to be nonfunctional relatives of genes and can be defined as fragments of nucleotide sequences that resemble a domain… Read More ›
Q-FISHing to monitor molecular aging
By Klaus D. Linse Fluorescence In Situ Hybridization (FISH) for Telomere Length Quantification or Q-FISH evolves into High-Throughput Q-FISH Fluorescence in situ hybridization (FISH) is a powerful tool and probes that exhibit high DNA and RNA affinities promise to improve… Read More ›
A brief history of Bridged Nucleic Acids (BNAs)
By Klaus D. Linse 01/03/2013 A quest for better oligonucleotide mimics. The quest for oligonucleotide mimics with improved characteristics and stabilities useful for molecular diagnostics and therapeutics that also show minimal side effects has led to the design and synthesis… Read More ›