Circular oligonucleotides are covalently closed singular DNA or RNA strands that are resistant to degradation by many cellular DNA and RNA decay machineries. [Source: (left) Modelling DNA; Phil. Trans. R. Soc. A-2006-Harris-3319-34; (right) David Goodsell: The self-splicing RNA in PDB… Read More ›
Micro RNAs (miRNAs) have recently emerged as key regulators of metabolic processes! . More and more evidence is accumulating that suggest that the dysregulation of miRNAs may contribute to metabolic abnormalities such as the misregulation of cholesterol and lipid metabolism, insulin… Read More ›
Answer 1 . A “nano-flare” refers to a very small solar flare that happens in the corona, the external atmosphere of the Sun. . Answer 2 . Nano-flares are a new class of intracellular molecular probes. . This blog is… Read More ›
Kirino & Mourelatos and Ohara et al. showed in 2007 that Piwi RNAs (piRNAs) are 2′-O-methylated at the 3′-end Several thousands of piwi RNA (piRNA) species that are typically 24–32 nucleotide (nt) long have been found in mammals, zebrafish, and… Read More ›
RNA FISH can be used to visualize subcellular locations of RNA or RNA-RBP complexes including the location of noncoding RNAs !
RNA FISH allows the identification and localization of noncoding RNAs in cells ! Ribonucleic Acid Fluorescence In Situ Hybridization (RNA FISH) is a visualization technique that allows simultaneous detection, localization, and quantification of individual RNA molecules at the subcellular level…. Read More ›
Bridged Nucleic Acid (BNA) based FISH probes are smart tools available from Biosynthesis Inc. Recent advancements in the design and development of molecular probes and image analysis has made fluorescence in situ hybridization (FISH) a powerful tool. Although being a… Read More ›